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EDA2R Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA550400

Catalog No. PA550400


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Description

Description

The antibody detects endogenous levels of total EDA2R protein.

X-linked ectodysplasin-A2 receptor (XEDAR) is a recently isolated member of the tumor necrosis factor receptor family that is highly expressed during embryonic development and binds to ectodysplatin-A2 (EDA-A2). Two predomitly expressed isoforms, XEDAR-s and XEDAR-L, differ by only a 21-amino region at the juxtamembrane region of the cytoplasmic domain. Neither isoform possesses a death domain and both have been shown to act mainly through TRAF3 and TRAF6 to activate the NF-kappa-B and JNK pathways. Cells transfected with XEDAR and treated with EDA-A2 cause the assembly of a secondary complex containing FADD, caspase-8 and caspase-10, leading to the activation caspase-8 and caspase-3, and finally apoptosis. The EDA-A2-induced apoptosis is dependent on caspase-9 activation, as various pharmacological and genetic inhibitors of caspase-8 blocked apoptosis following EDA-A2 treatment.
Specifications

Specifications

EDA2R
Polyclonal
Unconjugated
EDA2R
Liquid
EDA2R
Fusion protein corresponding to residues near the C terminal of human ectodysplasin A2 receptor
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Immunohistochemistry (Paraffin)
2.7 mg/mL
PBS with 50% glycerol and 0.05% sodium azide; pH 7.3
Q9HAV5
TNFRSF27, XEDAR
Rabbit
IgG
100 μL
-20°C
Primary
60401
Documents
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