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EID1 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA550401

Catalog No. PA550401


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Description

Description

The antibody detects endogenous levels of total EID1 protein.

E1A-like inhibitor of differentiation-1 (EID-1), an acetyltransferase enzyme, binds both the retinoblastoma protein (Rb), a regulator of cell cycle and tissue specific transcription, and the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. EID-1 inhibits cellular differentiation by blocking the histone acetyltransferase activity of p300. EID-1 also acetylates both histones and non-histone proteins such as NCOA3 co-activator. By acetylating histones, EID-1 gives a specific tag for transcriptional activation. In addition to binding Rb and p300, EID-1 also binds to phosphorylated CREB protein, mediating cAMP gene regulation. EID-1 augments the activity of phosphorylated CREB and activates transcription of cAMP responsive genes as a co-activator.
Specifications

Specifications

EID1
Polyclonal
Unconjugated
EID1
Liquid
EID1
Fusion protein corresponding to residues near the N terminal of human EP300 interacting inhibitor of differentiation 1
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Immunohistochemistry (Paraffin)
0.7 mg/mL
PBS with 50% glycerol and 0.05% sodium azide; pH 7.3
Q9Y6B2, Q9DCR4
C15orf3, CRI1, RBP21
Rabbit
IgG
100 μL
-20°C
Primary
23741, 58521
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