Invitrogen™ eIF2 gamma Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5100499

Catalog No. PIPA5100499

Description

Antibody detects endogenous levels of total EIF2G/EIF2S3.

The initiation of protein synthesis in eukaryotic cells is regulated by interactions between protein initiation factors and RNA molecules. The eukaryotic initiation complex is composed of three subunits, designated eIF2 alpha, eIF2 beta and eIF2 gamma (eukaryotic translation initiation factor 2 alpha, beta and gamma, respectively), all of which work in concert to form a ternary complex with GTP and tRNA in the early stages of protein synthesis. eIF2S3 (eukaryotic translation initiation factor 2, subunit 3), also known as eIF2G, is a 472 amino acid protein that belongs to the gamma subfamily of GTP-binding elongation factor proteins. Existing as a heterotrimer composed of an alpha, beta and gamma chain, eIF2S3 functions to bind ribosomal subunits and catalyze the subsequent formation of preinitiation complexes necessary for protein synthesis.

Specifications

• Antigen: eIF2 gamma
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: EIF2S3
• Gene Alias: EIF2; EIF2G; eIF-2gA; EIF2gamma; eIF-2-gamma; eIF-2-gamma X; eIF-2gX; Eif2s3; Eif2s3x; Eukaryotic translation initiation factor 2 subunit 3; Eukaryotic translation initiation factor 2 subunit 3, X-linked; Eukaryotic translation initiation factor 2 subunit gamma; eukaryotic translation initiation factor 2 subunit gamma X; Eukaryotic translation initiation factor 2 subunit gamma, X-linked; eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa; eukaryotic translation initiation factor 2, subunit 3, structural gene X-linked; eukaryotic translation initiation factor 2G; PP42
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 1968
• Content And Storage: -20°C
• Form: Liquid

• Applications: Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: P41091
• Gene Symbols: EIF2S3
• Immunogen: A synthesized peptide derived from human EIF2S3(Accession P41091), corresponding to amino acid residues A86-P136.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov