eIF3h Mouse anti-Human, Mouse, Clone: GT35512, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA527798
Positive Control: A431 Predicted Reactivity: Rat (99%), Xenopus laevis (86%), Chicken (95%), Bovine (98%) Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.eIF3H is a component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
|PBS with no preservative|
|EIF3H, EIF3S3, eIF3H / EIF3S3, eIF3H / EIF3S3, eIF3gamma, eIF3p40, eukaryotic translation initiation factor 3 subunit H|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot|
|Recombit protein encompassing a sequence within the center region of human eIF3H/EIF3S3. The exact sequence is proprietary.|
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