Invitrogen™ EIF4A1/EIF4A2/EIF4A3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5116950

Catalog No. PIPA5116950

Description

Positive Samples: 293T, HeLa, HepG2, MCF7, C2C12, Mouse brain, Rat brain Immunogen sequence: MSASQDSRSR DNGPDGMEPE GVIESNWNEI VDSFDDMNLS ESLLRGIYAY GFEKPSAIQQ RAILPCIKGY DVIAQAQSGT GKTATFAISI LQQIELDLKA.

The eIF4A proteins are involved in many aspects of RNA metabolism due to their RNA-binding capacity and ATPase activity. eIF4A1 and eIF4A2 are cytoplasmic, whereas eIF4A3 is nuclear-localized. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.

Specifications

• Antigen: EIF4A1/EIF4A2/EIF4A3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: EIF4A3
• Gene Alias: 2400003O03Rik; 4833432N07Rik; ATP-dependent RNA helicase DDX48; ATP-dependent RNA helicase eIF4A-1; ATP-dependent RNA helicase eIF4A-2; ATP-dependent RNA helicase eIF4A-3; BM-010; Ddx2a; Ddx2b; Ddx48; DEAD (Asp-Glu-Ala-Asp) box polypeptide 48; DEAD box protein 48; Eif4; EIF4A; EIF-4A; EIF4A1; EIF4A2; Eif4a3; eIF-4A-I; eIF4A-I; eIF-4A-II; eIF4A-II; eIF4AIII; eIF-4A-III; eIF4A-III; EIF4F; eukaryotic initiation factor 4AI; Eukaryotic initiation factor 4A-I; eukaryotic initiation factor 4A-II; Eukaryotic initiation factor 4A-III; Eukaryotic initiation factor 4A-III, N-terminally processed; Eukaryotic initiation factor 4A-like NUK-34; Eukaryotic translation initiation factor 4A isoform 3; eukaryotic translation initiation factor 4A, isoform 1; eukaryotic translation initiation factor 4A, isoform 2; eukaryotic translation initiation factor 4A, isoform 3; eukaryotic translation initiation factor 4A1; eukaryotic translation initiation factor 4A2; eukaryotic translation initiation factor 4A3; hNMP 265; initiation factor eIF-4A long form; KIAA0111; mKIAA0111; MUK34; NMP 265; NMP265; Nuclear matrix protein 265; NUK34; protein synthesis initiation factor 4AII; RCPS
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 13681, 13682, 192170, 1973, 1974, 287436, 303831, 688288, 9775
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot, Immunocytochemistry
• Concentration: 1.638 mg/mL
• Formulation: PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3
• Gene Accession No.: P10630, P38919, P60842, P60843, Q14240, Q3B8Q2, Q5RKI1, Q91VC3
• Gene Symbols: EIF4A1, EIF4A2, EIF4A3
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1-100 of human eIF4A (NP_0014071).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov