eIF6 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA5119721

Catalog No. PIPA5119721

Description

Positive Control: SHSY5Y cell lysate, A549 cell lysate, HepG2 cell lysate, human colon tissue, mouse colon tissue, SW620. Subcellular Location: Centromere, Chromosome, Nucleus.

Hemidesmosomes are structures which link the basal lamina to the intermediate filament cytoskeleton. An important functional component of hemidesmosomes is the integrin beta-4 subunit (ITGB4), a protein containing two fibronectin type III domains. The protein encoded by this gene binds to the fibronectin type III domains of ITGB4 and may help link ITGB4 to the intermediate filament cytoskeleton. The encoded protein, which is insoluble and found both in the nucleus and in the cytoplasm, can function as a translation initiation factor and prevent the association of the 40S and 60S ribosomal subunits. Multiple transcript variants encoding two different isoforms have been found for this gene.

Specifications

• Antigen: eIF6
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Eif6
• Gene Alias: 1110004P11; AA408895; b(2)gcn; B(2)GCN homolog; B4 integrin interactor; CAB; EIF3A; Eif6; eIF-6; eIF-6 {ECO:0000255; eukaryotic translation initiation factor 3A; eukaryotic translation initiation factor 6; eukaryotic translation initiation factor 6 {ECO:0000255; HAMAP-Rule:MF_03132}; imc-415; integrin beta 4 binding protein; Itgb4bp; OK/SW-cl.27; p27 beta-4 integrin-binding protein; p27(BBP); p27BBP
• Host Species: Rabbit
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 16418, 3692
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: TBS with 0.2% BSA, 50% glycerol and 0.05% sodium azide; pH 7.4
• Gene Accession No.: O55135, P56537
• Gene Symbols: Eif6
• Immunogen: Recombinant protein within human eIF-6 aa 1-200
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG