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Tocris™ Eliprodil

Non-competitive NR2B-selective NMDA antagonist

Manufacturer:  Tocris™ 2195/50

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Catalog No. 21-955-0

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For Research Use Only



Non-competitive NMDA receptor antagonist that acts at the polyamine modulatory site. Selective for NR2B- over NR2A- and NR2C-containing receptors (IC50 values are 1, > 100 and > 100µM respectively). Also σ1 ligand (Ki = 0.013µM). Antagonizes neuronal voltage-gated Ca2+ channels and selectively inhibits the rapid component of the delayed rectifier K+ current (IKr). Neuroprotective.
  • Chemical Name: α-(4-Chlorophenyl)-4-[(4-fluorophenyl)methyl]-1-piperidineethanol
  • Formula: C20H23ClFNO
  • CAS Number: 119431-25-3
  • Solubility: Soluble to 25mM in DMSO
  • Purity: >98
Description & Specifications


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