Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

Tocris™ Embelin

Inhibitor of X-linked inhibitor of apoptosis (XIAP); cell-permeable and antitumor

Manufacturer:  Tocris™ 2156/10

 View more versions of this product

Catalog No. 21-561-0R


  Check Availability
Add to cart

Disclaimers:

For Research Use Only


Specifications

Description

Cell-permeable, non-peptide inhibitor of X-linked inhibitor of apoptosis (XIAP) (IC50 = 4.1µM in competition binding assay with Smac peptide); binds to the BIR3 domain, preventing XIAP interaction with caspase-9 and Smac. Inhibits cell growth, induces apoptosis and activates caspase-9 in prostate cancer cells (IC50 4 - 6µM), but has a weaker effect on normal prostate cells (IC50 = 19 - 20µM). Overcomes the protective effect of XIAP on apoptosis in XIAP-transfected Jurkat cells. Anti-tumor, analgesic and anti-inflammatory in vivo.
  • Chemical Name: 2,5-Dihydroxy-3-undecyl-2,5-cyclohexadiene-1,4-dione
  • Formula: C17H26O4
  • CAS Number: 550-24-3
  • Solubility: Soluble to 10mM in ethanol with gentle warming and to 100mM in DMSO
  • Purity: >98
Description & Specifications

Specifications

Embelin
>99
10mg
Embelin
294.39
Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit