Inhibitor of X-linked inhibitor of apoptosis (XIAP); cell-permeable and antitumor
Manufacturer: Tocris 2156/10
DescriptionCell-permeable, non-peptide inhibitor of X-linked inhibitor of apoptosis (XIAP) (IC50 = 4.1µM in competition binding assay with Smac peptide); binds to the BIR3 domain, preventing XIAP interaction with caspase-9 and Smac. Inhibits cell growth, induces apoptosis and activates caspase-9 in prostate cancer cells (IC50 4 - 6µM), but has a weaker effect on normal prostate cells (IC50 = 19 - 20µM). Overcomes the protective effect of XIAP on apoptosis in XIAP-transfected Jurkat cells. Anti-tumor, analgesic and anti-inflammatory in vivo.
- Chemical Name: 2,5-Dihydroxy-3-undecyl-2,5-cyclohexadiene-1,4-dione
- Formula: C17H26O4
- CAS Number: 550-24-3
- Solubility: Soluble to 10mM in ethanol with gentle warming and to 100mM in DMSO
- Purity: >98
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