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MilliporeSigma™ 5-Lipoxygenase, Human, Recombinant Protein, S. fruigiperda

Supplier:  MilliporeSigma™ 437996500U

Catalog No. 43-799-6500U


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Description

Description

Recombinant, human 5-Lipoxygenase expressed in S. fruigiperda insect cells using a baculovirus overexpression system. 5-LO catalyzes the formation of 5(S)-HpETE from arachidonic acid and its subsequent conversion to leukotriene A4. It is localized in the cytosol of resting human and rat peripheral blood neutrophils, whereas it is found in the nucleus in rat basophilic leukemia cells and human alveolar macrophages. Upon stimulation of the cell, 5-LO translocates to the nuclear membrane where it is found in association with 5-LO activating protein (FLAP) and with the 85kDa cPLA2.
Specifications

Specifications

In 100mM Tris containing 5mM EGTA, pH 8.0.
S. fruigiperda
Following initial thaw, aliquot and freeze (−70°C).
Human
Liquid
500U
5-Lipoxygenase
RUO
Recombinant
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