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MilliporeSigma™ Chemicon™ Nerve Growth Factor 7.0s

130-140 kD protein composed of 3 subunits; 1 beta subunit (2.5S), 2 alpha subunits and 2 gamma subunits

Manufacturer:  MilliporeSigma™ NC010

Catalog No. NC010

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In the mouse submaxillary gland the neurotrophically active NGF, beta-NGF (2.5S), is part of a larger protein complex, 7S-NGF, which has the stoichiometry alpha2betagamma2 (+ 1 or 2 zinc ions) where the alpha and gamma subunits are members of the glandular kallikrein family of serine proteases, each of about 26 000 kDa molecular weight. The alpha and gamma subunits actually inhibit beta-NGF action and must be dissociated for biological activity to be observed.

This 7S complex has not been shown to occur in other mouse tissues, or in other species, probably because the alpha and gamma subunits, which are members of a larger glandular kallikrein family, apparently have a very restricted expression. The alpha and gamma subunits, members of the serine proteinase family, have quite similar amino acid sequences, although only the gamma subunit is catalytically active. The alpha subunit has undergone several mutations that preclude this function, including loss of the cleavage site needed for processing from the zymogen to the active form.



Mouse submaxillary gland (Darling and Shooter, 1984)
-20°C in undiluted aliquots for up to 6 months
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