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MilliporeSigma™ Orexin A (14-33) (Ab-2), Rabbbit Polyclonal, ChIP Validated Antibody and Primer Set

Rabbit Polyclonal Antibody

Manufacturer:  MilliporeSigma™ PC3621SET

Catalog No. PC3621SET

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

Specifically detects Orexin A (14-33) (Ab-2) Clone: in Bovine, Human, Mouse, Rat samples, and it is validated for ELISA, Immunofluorescence, Immunohistochemistry (Frozen)

The hypothalamus has been shown to play a central role in the regulation of energy homeostasis and in the control of feeding behavior. Two homologous peptides have recently been identified for which the message and protein have been localized to the lateral hypothalamus. Orexin A (hypocretin 1), a 33 amino acid peptide, and orexin B (hypocretin 2), a 28 amino acid peptide, are both encoded by a single mRNA transcript. These peptides stimulate food consumption in a dose-dependent manner when administered intracerebroventricularly, and precursor mRNA levels are upregulated upon fasting. In addition to the orexins (hypocretins), two G-protein coupled receptors, designated orexin receptor-1 and orexin receptor-2, have been identified which presumably mediate the signaling events from these neuropeptides. Competitive radioligand binding assays suggest that the orexin receptor-1 is selective for orexin A, while orexin receptor-2 is nonselective for both peptides.
Specifications

Specifications

Orexin A (14-33) (Ab-2)
Unconjugated
Undiluted Serum
a synthetic peptide (CRLYELLHGAGNHAAGILTL) corresponding to amino acids 14-33 of human orexin A
1 Set
−20°C
Polyclonal
Serum or ascites diluted in 5mM phosphate buffer, pH 7.5 and 25μg lyophilized control.
ELISA, Immunofluorescence, Immunohistochemistry (Frozen)
Serum or ascites diluted in 5mM phosphate buffer, pH 7.5 and 25μg lyophilized control.
Rabbit
IgG
RUO
Primary
Recognizes orexin A in mouse and rat brain. Supplied with a control peptide.
Bovine, Human, Murine, Rat
Documents
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