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Endothelin 3 Mouse anti-Human, Clone: OTI3E10, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA527028

Catalog No. PIMA527028


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Description

Description

The protein encoded by this gene is a member of the endothelin family. Endothelins are endothelium-derived vasoactive peptides involved in a variety of biological functions. The active form of this protein is a 21 amino acid peptide processed from the precursor protein. The active peptide is a ligand for endothelin receptor type B (EDNRB). The interaction of this endothelin with EDNRB is essential for development of neural crest-derived cell lineages, such as melanocytes and enteric neurons. Mutations in this gene and EDNRB have been associated with Hirschsprung disease (HSCR) and Waardenburg syndrome (WS), which are congenital disorders involving neural crest-derived cells. Four alternatively spliced transcript variants encoding three distinct isoforms have been observed.
Specifications

Specifications

Endothelin 3
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
P14138
EDN3;EDN3_HUMAN;Endothelin-3;ET 3;ET-3;PPET3;Preproendothelin 3;Preproendothelin-3;
Mouse
IgG1
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
1908
Immunohistochemistry (Paraffin)
OTI3E10
Unconjugated
EDN3
Liquid
EDN3
Human recombit protein fragment corresponding to amino acids 17-238 of EDN3 produced in E.coli
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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