ENG Mouse anti-Human, Clone: OTI9E5, liquid, TrueMAB
Mouse Monoclonal Antibody
Manufacturer: OriGene TA506169
DescriptionCD105 (Endoglin is a Type I transmembrane protein) is highly expressed on human vascular endothelial cells and exists on an O- and N-glycosylated homodimer. Up regulation of CD105 expression has been demonstrated in tumor vasculature and proliferating cells, suggesting that it is a proliferation associated endothelial marker. CD105 is highly expressed on endothelial cells and promotes angiogenesis during wound healing, infarcts and in a wide range of tumors and its gene expression is stimulated by hypoxia. CD105 binds to TGF beta 1 and 3 with high affinity but not to TGF beta 2. Mutations in the CD105 gene cause hereditary hemorrhagic telangiectasia, also known as Osler-Rendu-Weber syndrome 1, an autosomal domit multisystemic vascular dysplasia. Alternatively spliced transcript variants encoding different isoforms of CD105 have been found. Diseases associated with CD105 dysfunction include hereditary hemorrhagic telangiectasia.
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide|
|END, HHT1, ORW1|
|-20° C, Avoid Freeze/Thaw Cycles|
|Immunocytochemistry, Immunofluorescence, Western Blot|
|Full length human recombit protein of human ENg produced in HEK293T cell.|
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