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  7. Entacapone, Tocris Bioscience™

Entacapone, Tocris Bioscience™

Catalog Number 472050
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Quantity:
10 mg
50 mg
This item is not returnable. View return policy
130929-57-6
C14H15N3O5
305.29
MFCD00866580
JRURYQJSLYLRLN-BJMVGYQFSA-N
entacapone, comtan, comtess, entacaponum, entacapona, entacaponum inn-latin, entacapona inn-spanish, entacom, entacapone usan:inn, 2-cyano-n,n-diethyl-3-3,4-dihydroxy-5-nitrophenyl propenamide
5281081
CHEBI:4798
(2E)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethylprop-2-enamide
CCN(CC)C(=O)C(=C\C1=CC(O)=C(O)C(=C1)[N+]([O-])=O)\C#N
This item is not returnable. View return policy
130929-57-6
C14H15N3O5
305.29
MFCD00866580
JRURYQJSLYLRLN-BJMVGYQFSA-N
entacapone, comtan, comtess, entacaponum, entacapona, entacaponum inn-latin, entacapona inn-spanish, entacom, entacapone usan:inn, 2-cyano-n,n-diethyl-3-3,4-dihydroxy-5-nitrophenyl propenamide
5281081
CHEBI:4798
(2E)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethylprop-2-enamide
CCN(CC)C(=O)C(=C\C1=CC(O)=C(O)C(=C1)[N+]([O-])=O)\C#N

Description

Potent COMT inhibitor; blocks α-synuclein aggregation

Potent catechol O-methyltransferase (COMT) inhibitor (IC50 values are 14.3, 20.1 and 73.3 nM for rat liver soluble COMT, total COMT and membrane-bound COMT respectively). Increases bioavailability of levodopa when given as an adjunct therapy for Parkinson's disease. Inhibits α-synuclein aggregation in an in vitro assay; blocks α-synuclein-induced cell death in PC-12 cells.
Quantity 50 mg
Formula Weight 305.29
Percent Purity >99%
Chemical Name or Material Entacapone

Safety and Handling

Recommended Storage Store at Room Temperature
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