Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

EpCAM Rabbit anti-Human, Mouse, Rat, Unconjugated, Clone: ARC0521, Invitrogen™

Rabbit Monoclonal Antibody

Manufacturer:  Invitrogen MA535065

Catalog No. PIMA535065


Add to cart

Description

Description

Ep-CAM (epithelial adhesion molecule, epithelial specific antigen, ESA) is a transmembrane glycoprotein expressed in the epithelium with a molecular weight of approximately 40 kDa, which functions as an epithelial cell adhesion molecule. Ep-CAM functions as a homotypic calcium-independent cell adhesion molecule, and has a direct impact on cell cycle, proliferation and metabolism of epithelial cells and fibroblasts due to its ability to rapidly induce the proto-oncogene c-myc and the cell cycle regulating genes cyclin A and E. Ep-CAM mediates Ca2+-independent homotypic interactions. Formation of Ep-CAM-mediated adhesions have a negative regulatory effect on adhesions mediated by classic cadherins, which may have strong effects on the differentiation and growth of epithelial cells. Ep-CAM overexpression was suggested to be associated with enhanced epithelial proliferation. Ep-CAM is highly expressed in human carcinomas, and is a marker for tumors of epithelial lineage. Ep-CAM is expressed on baso-lateral cell surface in most simple epithelia and many carcinoma types. Also, Ep-CAM reportedly distinguishes adenocarcinomas from pleural mesotheliomas.
Specifications

Specifications

EpCAM
ARC0521
PBS with 50% glycerol and 0.2% sodium azide; pH 7.3
O55159, P16422, Q99JW5
Adenocarcinoma-associated antigen; CD326; Cell surface glycoprotein Trop-1; DIAR5; EGP; EGP-2; EGP314; EGP40; EPCAM; Ep-CAM; EpCAM1; Epithelial cell adhesion molecule; Epithelial cell surface antigen; Epithelial glycoprotein; Epithelial glycoprotein 314; ESA; GA733-2; gp40; hEGP314; HNPCC8; KS 1/4 antigen; KS1/4; KSA; Ly74; M1S2; M4S1; Major gastrointestinal tumor-associated protein GA733-2; MIC18; MK-1; Protein 289A; Protein D5.7A; Tacsd1; Tacstd1; TROP1; Tumor-associated calcium signal transducer 1
Rabbit
IgG
100 μL
-20°C, Avoid Freeze/Thaw Cycles
Primary
17075, 171577, 4072
Immunohistochemistry, Western Blot
Unconjugated
EPCAM
Liquid
EPCAM
A synthesized peptide derived from human EpCAM
Protein A
RUO
Antibody
Monoclonal
Human, Mouse, Rat
SDS
Documents
Product Certifications
Promotions

Promotions

Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit