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EpCAM Rabbit anti-Human, Mouse, Rat, Unconjugated, Clone: ARC0521, Invitrogen™

Rabbit Monoclonal Antibody

Manufacturer:  Invitrogen MA535065

Catalog No. PIMA535065

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Ep-CAM (epithelial adhesion molecule, epithelial specific antigen, ESA) is a transmembrane glycoprotein expressed in the epithelium with a molecular weight of approximately 40 kDa, which functions as an epithelial cell adhesion molecule. Ep-CAM functions as a homotypic calcium-independent cell adhesion molecule, and has a direct impact on cell cycle, proliferation and metabolism of epithelial cells and fibroblasts due to its ability to rapidly induce the proto-oncogene c-myc and the cell cycle regulating genes cyclin A and E. Ep-CAM mediates Ca2+-independent homotypic interactions. Formation of Ep-CAM-mediated adhesions have a negative regulatory effect on adhesions mediated by classic cadherins, which may have strong effects on the differentiation and growth of epithelial cells. Ep-CAM overexpression was suggested to be associated with enhanced epithelial proliferation. Ep-CAM is highly expressed in human carcinomas, and is a marker for tumors of epithelial lineage. Ep-CAM is expressed on baso-lateral cell surface in most simple epithelia and many carcinoma types. Also, Ep-CAM reportedly distinguishes adenocarcinomas from pleural mesotheliomas.


PBS with 50% glycerol and 0.2% sodium azide; pH 7.3
O55159, P16422, Q99JW5
Adenocarcinoma-associated antigen; CD326; Cell surface glycoprotein Trop-1; DIAR5; EGP; EGP-2; EGP314; EGP40; EPCAM; Ep-CAM; EpCAM1; Epithelial cell adhesion molecule; Epithelial cell surface antigen; Epithelial glycoprotein; Epithelial glycoprotein 314; ESA; GA733-2; gp40; hEGP314; HNPCC8; KS 1/4 antigen; KS1/4; KSA; Ly74; M1S2; M4S1; Major gastrointestinal tumor-associated protein GA733-2; MIC18; MK-1; Protein 289A; Protein D5.7A; Tacsd1; Tacstd1; TROP1; Tumor-associated calcium signal transducer 1
100 μL
-20°C, Avoid Freeze/Thaw Cycles
17075, 171577, 4072
Immunohistochemistry, Western Blot
A synthesized peptide derived from human EpCAM
Protein A
Human, Mouse, Rat
Product Certifications


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