Thermo Scientific Lab Vision Epidermal Growth Factor Receptor/EGFR Ab-1, Mouse Monoclonal Antibody
Obtain accurate, reproducible results in affinity purification, immunoprecipitation and flow cytometry experiments.
Manufacturer: Thermo Scientific MS268P1
Obtain accurate, reproducible results in affinity purification, immunoprecipitation and flow cytometry experiments with Thermo Scientific Epidermal Growth Factor Receptor/EGFR Ab-1, Mouse Monoclonal Antibody.EGFR is a type I receptor tyrosine kinase with sequence homology to erbB-1, -2, -3 -4 or HER-1, -2, -3 -4. It binds to Epidermal Growth Factor (EGF), Transforming Growth Factor-a (TGF-a), Heparin-binding EGF (HB-EGF), amphiregulin, βcellulin and epiregulin. EGFR is overexpressed in tumors of breast, brain, bladder, lung, gastric, head & neck, esophagus, cervix, vulva, ovary, and endometrium. It is predominantly present in squamous cell carcinomas.
Host Species: Mouse
Species Reactivity: Human and Dog. Does not react with mouse and rat. Others not known.
Epitope: Extracellular domain
Immunogen: Purified EGFR from A431 cells
Molecular Weight: 170 kDa (wild type) and 145 kDa (vIII variant)
Positive Control: A431 cells
Cellular Localization: Membrane
- Western Blotting (Not suitable)
- Affinity Purification
- Blocks EGF/TGFα-induced Activation of EGFR
- Inhibits Binding of EGFR Ab-2 (clone 225) to EGFR
- Inhibits Proliferation of A431 Cells
- Arrests Tumor Growth in vivo
- Immunoprecipitation (Native only)
- Flow Cytometry
USA: RUO; Int'l: RUO
|Epidermal Growth Factor Receptor /EGFR Ab-1|
|Purified EGFR from A431 cells|
|Flow Cytometry, Immunoprecipitation|
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