Invitrogen™ Epo Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA130182

Catalog No. PA130182

Description

PA1-30182 has been tested for its ability to neutralize the biological activity of EPO on the human cell line, TF1. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Erythropoietin (EPO) protein is a growth factor essential for the survival, proliferation, and differentiation of erythroid precursors. EPO is not responsible for early commitment to the lineage, and instead induces the final maturation of partially differentiated erythroid cells and the production of red cell-specific proteins, such as hemoglobin. The EPO receptor (EPOR) is present in higher levels on precursor cells, and expression diminishes with cell maturation.Hepatocytes are the main source of EPO in the fetus, followed by interstitial cells of the kidney after birth and through adulthood. EPO expression is upregulated during hypoxia, and low levels of transcription have also been detected in lung and brain tissue under these conditions. Recent data suggest that EPO may also play a role in the protection of neuronal tissue from damage and initiation of repair.

Specifications

• Antigen: Epo
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: EPO
• Gene Alias: EP; EPO; Epoetin; erythropoietin; MGC138142; MVCD2
• Host Species: Rabbit
• Purification Method: IgG fraction
• Regulatory Status: RUO
• Gene ID (Entrez): 2056
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: ELISA, Inhibition Assays, Immunohistochemistry (Paraffin), Neutralization, Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 5% trehalose and no preservative
• Gene Accession No.: P01588
• Gene Symbols: EPO
• Immunogen: Recombinant full length erythropoietin (Human), expressed in CHO cells.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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