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  7. 3502100U

Epothilone B, Tocris Bioscience™

Catalog Number 3502100u
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Quantity:
100 μg
This item is not returnable. View return policy
152044-54-7
C27H41NO6S
507.69
MFCD02101921
QXRSDHAAWVKZLJ-PVYNADRNSA-N
epothilone b, patupilone, --epothilone b, epo b, epob, unii-uec0h0urse, epo 906a, gnf-pf-193, uec0h0urse, epothilone b epo906, patupilone
448013
CHEBI:42432
(1S,3S,7S,10R,11S,12S,16R)-7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-[(1E)-1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione
C[C@H]1CCC[C@@]2(C)O[C@H]2C[C@H](OC(=O)C[C@H](O)C(C)(C)C(=O)[C@H](C)[C@H]1O)C(\C)=C\C1=CSC(C)=N1
This item is not returnable. View return policy
152044-54-7
C27H41NO6S
507.69
MFCD02101921
QXRSDHAAWVKZLJ-PVYNADRNSA-N
epothilone b, patupilone, --epothilone b, epo b, epob, unii-uec0h0urse, epo 906a, gnf-pf-193, uec0h0urse, epothilone b epo906, patupilone
448013
CHEBI:42432
(1S,3S,7S,10R,11S,12S,16R)-7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-[(1E)-1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione
C[C@H]1CCC[C@@]2(C)O[C@H]2C[C@H](OC(=O)C[C@H](O)C(C)(C)C(=O)[C@H](C)[C@H]1O)C(\C)=C\C1=CSC(C)=N1

Description

Microtubule stabilization agent; promotes tubulin polymerization

Microtubule stabilization agent that promotes tubulin polymerization and induces G2-M cell cycle arrest (EC50 = 32 nM in HeLa cells). Inhibits proliferation of human carcinoma cell lines in vitro, including MDR cells overexpressing the P-glycoprotein efflux pump. Exhibits potent cytotoxicity in MCF-7 and A549 cells (EC50 values are 0.3 and 2.7 nM respectively). Inhibits growth of HCT-15 tumors in mice in vivo.
Quantity 100 μg
Formula Weight 507.68
Percent Purity >98%
Chemical Name or Material Epothilone B

Safety and Handling

Recommended Storage Store at -20°C
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