EPS15L, Polyclonal, Bethyl Laboratories
Rabbit Polyclonal Antibody
Manufacturer: Bethyl Laboratories, Inc A301731AM
The recommended shelf life for this product is 1 year from date of receipt.Ubiquitin is a 76 amino acid highly conserved eukaryotic polypeptide that selectively marks cellular proteins for proteolytic degradation by the 26S proteasome. The process of target selection, covalent attachment and shuttle to the 26S proteasome is a vital means of regulating the concentrations of key regulatory proteins in the cell by limiting their lifespans. Polyubiquitination is a common feature of this modification. Serial steps for modification include the activation of ubiquitin, an ATP-dependent formation of a thioester bond between ubiquitin and the enzyme E1, transfer by transacylation of ubiquitin from E1 to the ubiquitin conjugating enzyme E2, and covalent linkage to the target protein directly by E2 or via E3 ligase enzyme. Deubiquitination enzymes also exist to reverse the marking of protein substrates. Posttranslational tagging by Ub is involved in a multitude of cellular processes, including the cell cycle, cell growth and differentiation, embryogenesis, apoptosis, signal transduction, DNA repair, regulation of transcription and DNA replication, transmembrane transport, stress responses, the immune response, and nervous system functions.
|TBS with 0.1% BSA and 0.09% sodium azide|
|Epidermal growth factor receptor substrate 15-like 1; Eps15-related protein; EPS15L1|
|Between 814 and 864|
|Antigen affinity chromatography|
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