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EPS15R Rabbit anti-Human, Polyclonal, Proteintech Non-distribution product as customer accommodation.

Rabbit Polyclonal Antibody

Manufacturer:  Proteintech Group IncSupplier Diversity Partner 212431AP

Catalog No. 50-173-3334


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Description

Description

Ubiquitin is a 76 amino acid highly conserved eukaryotic polypeptide that selectively marks cellular proteins for proteolytic degradation by the 26S proteasome. The process of target selection, covalent attachment and shuttle to the 26S proteasome is a vital means of regulating the concentrations of key regulatory proteins in the cell by limiting their lifespans. Polyubiquitination is a common feature of this modification. Serial steps for modification include the activation of ubiquitin, an ATP-dependent formation of a thioester bond between ubiquitin and the enzyme E1, transfer by transacylation of ubiquitin from E1 to the ubiquitin conjugating enzyme E2, and covalent linkage to the target protein directly by E2 or via E3 ligase enzyme. Deubiquitination enzymes also exist to reverse the marking of protein substrates. Posttranslational tagging by Ub is involved in a multitude of cellular processes, including the cell cycle, cell growth and differentiation, embryogenesis, apoptosis, signal transduction, DNA repair, regulation of transcription and DNA replication, transmembrane transport, stress responses, the immune response, and nervous system functions.
Specifications

Specifications

EPS15R
0.5 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Q9UBC2
Eps15 related protein, EPS15L1, EPS15R
Rabbit
IgG
150 μL
-20°C
Primary
58513
Immunocytochemistry, Immunofluorescence, Western Blot
Unconjugated
EPS15L1
Liquid
EPS15L1
EPS15R Fusion Protein Ag15735
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human
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