ER beta/NR3A2 Mouse anti-Human, Mouse, Rat, Porcine, Equine, Primate, Sheep, Alexa Fluor 532, Clone: ERb455, Novus Biologicals
Mouse Monoclonal Antibody
Manufacturer: Novus Biologicals NBP233066AF532
DescriptionER beta/NR3A2 Monoclonal antibody specifically detects ER beta/NR3A2 in Human,Mouse,Rat,Porcine,Equine,Primate,Sheep samples. It is validated for Western Blot,ELISA,Immunohistochemistry,Immunocytochemistry,Immunofluorescence,Immunohistochemistry (Paraffin),Immunohistochemistry (Frozen).
|Western Blot, ELISA, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen|
|Erb, ER-beta, ESR-BETA, ESTRB, estrogen receptor 2 (ER beta), estrogen receptor beta, estrogen receptor beta 4, NR3A2ESRB, Nuclear receptor subfamily 3 group A member 2|
|Store at 4°C in the dark.|
|Estrogen receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of ligand-activated transcription factors. Estrogen receptors, including ER-alpha and ER-beta, contain DNA binding and ligand binding domains and are critically involved in regulating the normal function of reproductive tissues. They are located in the nucleus, though some estrogen receptors associate with the cell surface membrane and can be rapidly activated by exposure of cells to estrogen. ER-alpha and ER-beta are differentially activated by various ligands. Receptor-ligand interactions trigger a cascade of events, including dissociation from heat shock proteins, receptor dimerization, phosphorylation and the association of the hormone activated receptor with specific regulatory elements in target genes. Evidence suggests that ER-alpha and ER-beta may be regulated by distinct mechanisms even though they share many functional characteristics.|
|ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunohistochemistry (Paraffin), Western Blot|
|Alexa Fluor™ 532|
|50 mM sodium borate with 0.05% sodium azide|
|A recominant protein fragment specific to Estrogen Receptor beta was used as the immunogen for the ERb455 antibody.|
|Equine, Human, Mouse, Porcine, Primate, Rat, Sheep|
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