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ER beta/NR3A2 Mouse anti-Human, Mouse, Rat, Porcine, Equine, Primate, Sheep, Alexa Fluor™ 750, Clone: ERb455, Novus Biologicals™

Mouse Monoclonal Antibody

Manufacturer:  Novus BiologicalsSupplier Diversity Partner NBP233066AF750

Catalog No. NP233066A70


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Description

Description

ER beta/NR3A2 Monoclonal antibody specifically detects ER beta/NR3A2 in Human,Mouse,Rat,Porcine,Equine,Primate,Sheep samples. It is validated for Western Blot,ELISA,Immunohistochemistry,Immunocytochemistry,Immunofluorescence,Immunohistochemistry (Paraffin),Immunohistochemistry (Frozen).
Specifications

Specifications

ER beta/NR3A2
ERb455
Western Blot, ELISA, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen
Erb, ER-beta, ESR-BETA, ESTRB, estrogen receptor 2 (ER beta), estrogen receptor beta, estrogen receptor beta 4, NR3A2ESRB, Nuclear receptor subfamily 3 group A member 2
Mouse
IgG2a
Store at 4°C in the dark.
Monoclonal
Estrogen receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of ligand-activated transcription factors. Estrogen receptors, including ER-alpha and ER-beta, contain DNA binding and ligand binding domains and are critically involved in regulating the normal function of reproductive tissues. They are located in the nucleus, though some estrogen receptors associate with the cell surface membrane and can be rapidly activated by exposure of cells to estrogen. ER-alpha and ER-beta are differentially activated by various ligands. Receptor-ligand interactions trigger a cascade of events, including dissociation from heat shock proteins, receptor dimerization, phosphorylation and the association of the hormone activated receptor with specific regulatory elements in target genes. Evidence suggests that ER-alpha and ER-beta may be regulated by distinct mechanisms even though they share many functional characteristics.
ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunohistochemistry (Paraffin), Western Blot
Alexa Fluor™ 750
50 mM sodium borate with 0.05% sodium azide
ESR2
A recominant protein fragment specific to Estrogen Receptor beta was used as the immunogen for the ERb455 antibody.
0.1 mL
Primary
2100
Equine, Human, Mouse, Porcine, Primate, Rat, Sheep
Documents
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