ER-HR3 Rat anti-Mouse, Clone: ER-HR3, Novus Biologicals™

Rat Monoclonal Antibody has been used in 1 publication

Catalog Number	Mfr. No.	Quantity
NB10064931	Novus Biologicals NB10064931	0.125 mg
NB017667	Novus Biologicals NB100649310.025MG	0.025 mg

Description

ER-HR3 Monoclonal specifically detects ER-HR3 in Mouse samples. It is validated for Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Frozen.

Specifications

• Antigen: ER-HR3
• Concentration: 1.0 mg/mL
• Applications: Flow Cytometry, Immunohistochemistry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Frozen)
• Conjugate: Unconjugated
• Host Species: Rat
• Target Species: Mouse
• Immunogen: Adherent F1 (CBAxBL) bone marrow stormal cells.
• Primary or Secondary: Primary
• Content And Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

• Clone: ER-HR3
• Dilution: Flow Cytometry 1:10-1:50, Immunohistochemistry 1:10-1:500, Immunocytochemistry/Immunofluorescence 1:10-1:500, Immunohistochemistry-Frozen 1:10-1:500
• Classification: Monoclonal
• Form: Purified
• Regulatory Status: RUO
• Gene Alias: Hematopoiesis related macrophage
• Isotype: IgG2c
• Purification Method: Protein G purified
• Test Specificity: NB100-64931 recognizes the murine antigen ER-HR3. ER-HR3 is a cell surface antigen which is expressed by Langerhans cells in epithelium, a subset of mature macrophages and dendritic cells that are located predominantly in haematopoietic and lymphoid organs. Initial studies of ER-HR3 demonstrated expression on peripheral blood monocytes but recent studies suggest that expression is actually very low. During foetal development, ER-HR3 positive cells are localised to haemapoietic islands and are often associated with erythroid progenitor cells. The functions of the ER-HR3 antigen have not been established but reports suggest that the antigen may be involved in adult erythropoiesis and in the regulation of the immune response. Clone ER-HR3 does not inhibit T cell proliferation in antigen-specific T-cell proliferation studies. Clone ER-HR3 recognizes two proteins of approximately 69kD and 55kD under non-reducing conditions.

For Research Use Only