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ERAB Mouse anti-Human, Clone: OTI11A2, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA525002

Catalog No. PIMA525002


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Description

Description

Mutations in several genes associated with early onset Alzheimer ft.s result in increased extracellular concentrations of the longer form of the beta-amyloid peptide Ab 1-42 relative to Ab 1-40. It is this longer form of Ab that has been shown to be toxic to neurons and may serve as a catalyst for the aggregation and deposition of Ab to produce the neurotoxic effects associated with senile plaque formation. Using the Ab peptide in a yeast two-hybrid screen, a novel interacting protein designated the endoplasmic reticulum-associated amyloid beta-peptide-binding protein (ERAB)/L-3-hydroxyacyl-CoA dehydrogenase type II has been identified. It is shown to be expressed at high levels in Alzheimer ft.s disease-affected brain. ERAB may contribute to neuronal dysfunction in Alzheimer ft.s disease.
Specifications

Specifications

ERAB
Monoclonal
0.89 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Q99714
17b-HSD10, ABAD, CAMR, DUPXp11.22, ERAB, HADH2, HCD2, MHBD, MRPP2, MRX17, MRX31, MRXS10, SCHAD, SDR5C1, 3-hydroxy-2-methylbutyryl-CoA dehydrogenase, 3-hydroxyacyl-CoA dehydrogenase type-2, AB-binding alcohol dehydrogenase, amyloid-beta peptide binding alcohol dehydrogenase, endoplasmic reticulum-associated amyloid beta-peptide-binding protein, mitochondrial RNas
Mouse
IgG2b
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
3028
Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
OTI11A2
Unconjugated
HSD17B10
Liquid
HSD17B10
Full length human recombit protein of HSD17B10 produced in HEK293T cell
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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