Invitrogen™ ERAS Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5101616

Catalog No. PIPA5101616

Description

Antibody detects endogenous levels of total ERAS.

The human ERAS gene was initially reported as a processed pseudogene (HRasp, Ha-Ras2), with several base substitutions in coding regions, but was more recently described as potentially encoding a functional human ERAS protein. The ERAS oncogene supports the tumorigenic growth of embryonic stem cells by producing a constitutively active Ras protein. ERAS protein has less than 50% amino acid identity with H-Ras, another member of Ras family but the key domains essential for Ras function are highly conserved. The protein also contains amino-acid residues identical to those present in active mutants of Ras and causes oncogenic transformation in NIH 3T3 cells. Human ERAS gene is localized in the chromosomal region Xp11.23.

Specifications

• Antigen: ERAS
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ERAS
• Gene Alias: ecat5; Embryonic stem cell-expressed Ras; ERAS; E-Ras; ES cell expressed Ras; ES cell-expressed Ras; GTPase ERas; Ha-Ras2; HRAS2; HRasp; small GTPase E-Ras; small GTPase protein E-Ras; v-Ha-ras Harvey rat sarcoma viral oncogene homolog 2; v-Ha-ras Harvey rat sarcoma viral oncogene homolog pseudogene
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 3266
• Content And Storage: -20°C
• Form: Liquid

• Applications: Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: Q7Z444
• Gene Symbols: ERAS
• Immunogen: A synthesized peptide derived from human ERAS(Accession Q7Z444), corresponding to amino acid residues H197-A233.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov