ERK1/2 Rabbit anti-Human, Mouse, Rat, Zebrafish, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Manufacturer: Proteintech Group Inc 164431AP
This antibody can recognize both ERK1 and ERK2 with the molecular mass of 38-43 kDa.MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. The p44/42 MAPK (Erk1/2) are members of mitogen-activated kinases (MAPKs) of serine/threonine protein kinases. Phospho ERK1/2 can be activated by a range of extracellular stimuli, such as mitogen, growth factors, neurotransmitters, chemokines, and cytokines, through receptor tyrosine kinases (RTK), G protein-coupled receptors (GPCRs), or protein kinase C (PKC). Upstream MEK1 and MEK2 activate p44 and p42 (phospho ERK1/2) through phosphorylation of activation loop residues Thr202/Tyr204 and Thr185/Tyr187, respectively. p44/42 (ERK1/2) are negatively regulated by a family of dual-specificity (Thr/Tyr) MAPK phosphatases, known as DUSPs or MKPs, along with MEK inhibitors, such as U0126 and PD98059.
|PBS with 50% glycerol and 0.02% sodium azide; pH 7.3|
|P21708, P27361, P28482, P63085, P63086, Q63844|
|ERK, ERK 2, ERK1/2, ERK2, ERT1, MAP kinase 1, MAP kinase 2, MAP kinase isoform p42, MAPK 1, MAPK 2, MAPK1, MAPK2, p40, p41, p41mapk, p42 MAPK, P42MAPK, PRKM1, PRKM2|
|116590, 26413, 26417, 360144, 399480, 50689, 5594, 5595|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot|
|ERK1/2 Fusion Protein Ag9772|
|Antigen Affinity Chromatography|
|Human, Mouse, Rat, Zebrafish|
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