ESAM Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Supplier: Thermo Scientific PA588422
Immunogen sequence: QLQLHLPANR LQAVEGGEVV LPAWYTLHGE VSSSQPWEVP FVMWFFKQKE KEDQVLSYIN GVTTSKPGVS LVYSMPSRNL SLRLEGLQEK DSGPYSCSVN VQDKQGKSRG HSIKTLELNV LVPPAPPSCR LQGVPHVGAN VTLSCQSPRS KPAVQYQWDR QLPSFQTFFA PALDVIRGSL SLTNLSSSMA GVYVCKAHNE VGTAQCNVTL EVSTGPGAA; Positive Samples: HT-29, HepG2, 293T, A-549; Cellular Location: Cell junction, Cell membrane, Single-pass type I membrane protein, adherens junction, tight junctionESAM is a 55-kDa membrane protein composed of 2 extracellular Ig domains, a single transmembrane domain, and a 120 amino acid cytoplasmic domain. ESAM is related to members of the junctional adhesion molecule (JAM) family, and is expressed on endothelial cells and activated platelets. ESAM at endothelial tight junctions plays a role in the regulation of vascular permeability, in response to agents such as VEGF or extravasating neutrophils.
|Recombit fusion protein containing a sequence corresponding to amino acids 30-248 of human ESAM|
|PBS with 50% glycerol and 0.02% sodium azide; pH 7.3|
|Antigen Affinity Chromatography|
|-20° C, Avoid Freeze/Thaw Cycles|
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