ETF1 Mouse anti-Human, Clone: OTI2E3, liquid, TrueMAB
Mouse Monoclonal Antibody
Manufacturer: OriGene TA502891
DescriptionTermination of protein biosynthesis and release of the nascent polypeptide chain are signaled by the presence of an in-frame stop codon at the aminoacyl site of the ribosome. The process of translation termination is universal and is mediated by protein release factors (RFs) and GTP. A class 1 RF recognizes the stop codon and promotes the hydrolysis of the ester bond linking the polypeptide chain with the peptidyl site tRNA, a reaction catalyzed at the peptidyl transferase center of the ribosome. Class 2 RFs, which are not codon specific and do not recognize codons, stimulate class 1 RF activity and confer GTP dependency upon the process. In prokaryotes, both class 1 RFs, RF1 and RF2, recognize UAA; however, UAG and UGA are decoded specifically by RF1 and RF2, respectively. In eukaryotes, eRF1, or ETF1, the functional counterpart of RF1 and RF2, functions as an omnipotent RF, decoding all 3 stop codons.
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide|
|D5S1995, ERF, ERF1, RF1, SUP45L1, TB3-1|
|-20° C, Avoid Freeze/Thaw Cycles|
|Flow Cytometry, Western Blot|
|Full length human recombit protein of human ETF1 produced in HEK293T cell.|
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