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EXD1 Mouse anti-Human, Non-human primate, Rat, Clone: OTI2G5, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA525350

Catalog No. PIMA525350


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Description

Description

EXD1 is an RNA-binding component of the PET complex, a multiprotein complex required for the processing of piRNAs during spermatogenesis. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposable elements, preventing their mobilization, which is essential for the germline integrity. The PET complex is required during the secondary piRNAs metabolic process for the PIWIL2 slicing-triggered loading of PIWIL4 piRNAs. In the PET complex, EXD1 probably acts as an RNA adapter. EXD1 is an inactive exonuclease.
Specifications

Specifications

EXD1
Monoclonal
0.6 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Q8NHP7
EXD1, EXDL1
Mouse
IgG1
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
161829, 311334, 705364
Flow Cytometry, Western Blot
OTI2G5
Unconjugated
EXD1
Liquid
Exd1
Full length human recombit protein of EXD1 produced in HEK293T cell
Affinity Chromatography
RUO
Antibody
Monoclonal
Human, Non-human primate, Rat
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