Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

EXOSC7 Mouse anti-Human, Clone: OTI1F4, liquid, TrueMAB™ Non-distribution product as customer accommodation.

Mouse Monoclonal Antibody

Manufacturer:  OriGeneSupplier Diversity Partner TA504244

Catalog No. 50-167-4971


Add to cart

Description

Description

Non-catalytic component of the RNA exosome complex which has 3 ft.->5 ft. exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding  ft.pervasive ft. transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3 ft. untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes.
Specifications

Specifications

EXOSC7
Monoclonal
0.91 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Q15024
EAP1, RRP42, Rrp42p, hRrp42p, p8
Mouse
IgG1
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
23016
Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
OTI1F4
Unconjugated
EXOSC7
Liquid
EXOSC7
Full length human recombit protein of human EXOSC7 produced in HEK293T cell.
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
Provide Content Correction

The Fisher Scientific Encompass Program offers items which are not part of our distribution portfolio. These products typically do not have pictures or detailed descriptions. However, we are committed to improving your shopping experience. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit