Invitrogen™ EYA2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA555487

Catalog No. PIPA555487

Description

Immunogen sequence: GTTGFYQGGN GLGNAAGFGS VHQDYPSYPG FPQSQYPQYY GSSYNPPYVP ASSICPSPLS TSTYVLQEAS HNVPNQSSES LAGEYNTHNG PSTPAKEGDT DRPHRASDGK LRGRSKRSSD PSPAGDNEIE RVFVWDLD Highest antigen sequence identity to the following orthologs: Mouse - 86%, Rat - 88%.

Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5. Tyrosine phosphatase that dephosphorylates 'Tyr- 142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis. Plays an important role in hypaxial muscle development together with SIX1 and DACH2; in this it is functionally redundant with EYA1.

Specifications

• Antigen: EYA2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: EYA2
• Gene Alias: Drosophila-type eyes absent 2-like protein; Eab1; EYA transcriptional coactivator and phosphatase 2; Eya2; eyes absent 2; eyes absent 2 homolog; eyes absent 2 homolog (Drosophila); eyes absent 2 isoform a; eyes absent homolog 2
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 2139
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.2 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: O00167
• Gene Symbols: EYA2
• Immunogen: Recombinant protein corresponding to Human EYA2. Recombinant protein control fragment (Product #RP-91554).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG