EYA2 Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA548817
DescriptionFunctions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5. Tyrosine phosphatase that dephosphorylates ft.Tyr- 142 ft. of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. ft.Tyr-142 ft. phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis. Plays an important role in hypaxial muscle development together with SIX1 and DACH2; in this it is functionally redundant with EYA1.
|PBS with 0.09% sodium azide|
|Eyes absent homolog 2, EYA2, EAB1|
|-20° C, Avoid Freeze/Thaw Cycles|
|KLH conjugated synthetic peptide between 216-244 amino acids from the Central region of human EYA2.|
|Antigen affinity chromatography|
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