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EYA2 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA548817

Catalog No. PA548817

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5. Tyrosine phosphatase that dephosphorylates  ft.Tyr- 142 ft. of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1.  ft.Tyr-142 ft. phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis. Plays an important role in hypaxial muscle development together with SIX1 and DACH2; in this it is functionally redundant with EYA1.
Specifications

Specifications

EYA2
Polyclonal
PBS with 0.09% sodium azide
O00167
Eyes absent homolog 2, EYA2, EAB1
Rabbit
IgG
400 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
2139
Western Blot
Unconjugated
EYA2
Liquid
EYA2
KLH conjugated synthetic peptide between 216-244 amino acids from the Central region of human EYA2.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Documents
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