Factor VIII Related Antigen/von Willebrand Factor Ab-1 Rabbit Polyclonal Antibody, Epredia™

Obtain accurate, reproducible results in immunohistochemistry and immunofluorescence experiments.

Supplier:  Epredia RB281A0

Catalog No. RB281A0

Description

Factor VIII related antigen or von Willebrand factor is a multimeric glycoprotein. It has functional binding domains to platelet glycoprotein Ib, glycoprotein IIb/IIIa, collagen and heparin. von Willebrand factor is synthesized by endothelial cells and stored in the Weibel-Palade granules. It mediates platelet adhesion to injured vessel walls and serves as a carrier and stabilizer for coagulation factor VIII. von Willebrand factor is one of the most useful markers to identify endothelial (or megakaryocytic) lineage of neoplasms. As not all endothelial cells synthesize/store this molecule, about 30% of tumors of vascular origin fail to stain for factor VIII related antigen, regardless of whether they are benign or malignant. Staining for factor VIII related antigen has also been used to measure angiogenesis an indicator of tumor recurrence.

Host Species: Rabbit

Isotype: IgG

Species Reactivity: Human. Others not known.

Epitope: Not determined

Immunogen: Purified factor VIII related antigen/von Willebrand factor

Molecular Weight: 270 kDa

Positive Control: Tonsil

Cellular Localization: Cytoplasmic

Recommended for:

• Immunohistochemistry (Formalin/paraffin)
• Immunofluorescence

Specifications

• Antigen: Factor VIII Related Antigen/von Willebrand Factor Ab-1
• Classification: Polyclonal
• Host Species: Rabbit
• Quantity: 100 μL
• Research Discipline: Hematopoietic
• Target Species: Human
• Isotype: IgG

• Applications: Immunohistochemistry (Paraffin)
• Conjugate: Unconjugated
• Immunogen: Purified factor VIII related antigen/von Willebrand factor
• Regulatory Status: IVD
• Primary or Secondary: Primary
• Form: Concentrated