Factor XII Heavy chain Monoclonal Antibody (B7C9), Invitrogen™

Mouse Monoclonal Antibody

Supplier:  Thermo Scientific MA110828

Catalog No. 01-671-856

Description

MA1-10828 detects Factor XII heavy chain, from human samples. MA1-10828 has been successfully used in ELISA and Western blot applications. By Western blot, this antibody detects a ∽50 kDa band representing the non-reduced heavy chain of Factor XII from normal human plasma . The MA1-10828 immunogen is purified human Factor XII.

Hemostasis following tissue injury involves the deployment of essential plasma procoagulants which are involved in a blood coagulation cascade leading to the formation of insoluble fibrin clots and the promotion of platelet aggregation. Factor XII, (FXII) a blood coagulation factor, is a serum glycoprotein that participates in fibrinolysis, as well as the generation of bradykinin and angiotensin. An enzyme of the serine protease (or serine endopeptidase) class, it activates both Factor XI and prekallikrein in the coagulation cascade. Factor XII deficiency, a rare hereditary disorder slightly more prevalent among Asians, does not cause excessive hemorrhaging since other coagulation factors compensate for it. Researchers have still reported Factor XII deficiency to be a risk factor for the development of arterial and venous thromboembolism. The gene for human Factor XII maps to the very end of the long arm of the fifth chromosome (5q33-qter).

Specifications

• Antigen: Factor XII Heavy chain
• Classification: Monoclonal
• Concentration: 1.4 mg/mL
• Formulation: PBS with no preservative; pH 7.4
• Gene Accession No.: P00748
• Gene Symbols: F12
• Immunogen: Purified human Factor XII.
• Quantity: 250 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: ELISA, Western Blot
• Clone: B7C9
• Conjugate: Unconjugated
• Gene: F12
• Gene Alias: Beta-factor XIIa part 1; beta-factor XIIa part 2; Coagulation factor XII; coagulation factor XII (Hageman factor); coagulation factor XIIa heavy chain; Coagulation factor XIIa light chain; F12; Factor 12; factor XII; Factor12; FXII; HAE3; HAEX; HAF; Hageman factor
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 2161
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid