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FADD Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech Non-distribution product as customer accommodation.

Rabbit Polyclonal Antibody

Manufacturer:  Proteintech Group IncSupplier Diversity Partner 149061AP

Catalog No. 50-172-9823


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Description

Description

The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development.
Specifications

Specifications

FADD
0.13 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Q13158, Q61160
FADD, GIG3, MORT1, Protein FADD
Rabbit
IgG
150 μL
-20°C
Primary
14082, 266610, 8772
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Unconjugated
FADD
Liquid
FADD
FADD Fusion Protein Ag6701
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
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