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FADD Mouse anti-Human, Clone: OTI1C11, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA525179

Catalog No. PIMA525179


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Description

Description

FADD (Fas Associated Death Domain) is an apoptosis adapter molecule enabling transduction of the apoptosis signal initiated via the FasL/Fas receptor interaction. The protein contains a C-terminal death domain that interacts with the Fas receptor death domain. The N-terminus contains a death effectors domain (DED, which recruits caspase to the death inducing signaling complex (DISC) and initiates the apoptotic caspase cascade. FADD is implicated in non-apoptotic cellular pathways such as the regulation of cell cycle machinery in T lymphocytes. This is connected to the phosphorylation state of FADD and to the FasL/TRAIL-induced transcriptional activation of c-fos protooncogene. FADD also interacts with the hepatitis C virus core protein in the HEK-293 cell line.
Specifications

Specifications

FADD
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Q13158
FAS-associated death domain protein; Fas-associating death domain-containing protein; Fas-associating protein with death domain; growth-inhibiting gene 3 protein; mediator of receptor induced toxicity; mediator of receptor-induced toxicity; protein FADD
Mouse
IgG1
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
8772
Flow Cytometry, Western Blot
OTI1C11
Unconjugated
FADD
Liquid
FADD
Full length human recombit protein of FADD produced in HEK293T cell
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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