FBXO8 Mouse anti-Human, Clone: OTI3C5, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA526888
DescriptionThis gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. It contains a C-terminal amino acid sequence that bears a significant similarity with a portion of yeast Sec7p, a critical regulator of vesicular protein transport. This human protein may interact with ADP-ribosylation factor(s)(ARFs) and exhibit ARF-GEF (guanine nucleotide exchange factor) activity.
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3|
|FBS, FBX8, F-box only protein 8, F-box protein Fbx8, F-box/SEC7 protein FBS|
|-20° C, Avoid Freeze/Thaw Cycles|
|Immunohistochemistry (Paraffin), Western Blot|
|Human recombit protein fragment corresponding to amino acids 1-231 of FBXO8 produced in E.coli|
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