FBXW7 Mouse anti-Human, Clone: OTI6B1, lyophilized, TrueMAB™ 

Mouse Monoclonal Antibody

Manufacturer:  OriGene CF803051

Catalog No. 50-166-6306

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

Cyclin E, one of the activators of the cyclin-dependent kinase Cdk2, is critical for the initiation of DNA replication and other S-phase functions. The proper timing and amplitude of cyclin E expression seem to be important, because elevated levels of cyclin E have been associated with a variety of maligcies and constitutive expression of cyclin E leads to genomic instability. Phosphorylated cyclin E depends on the novel human gene, hCdc4, that was found to be mutated in a cell line derived from breast cancer that expressed extremely high levels of cyclin E.

Specifications

• Antigen: FBXW7
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: FBXW7
• Format: Lyophilized
• Gene Symbols: FBXW7
• Immunogen: Human recombit protein fragment corresponding to amino acids 1-354 of human FBXW7 produced in E.coli.
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Type: Antibody
• Monoclonal or Polyclonal: Monoclonal
• Target Species: Human

• Applications: Western Blot
• Clone: OTI6B1
• Formulation: PBS with 8% trehalose and no preservative; pH 7.3
• Gene Accession No.: Q969H0
• Gene Alias: AGO, CDC4, FBW6, FBW7, FBX30, FBXO30, FBXW6, SEL-10, SEL10, hAgo, hCdc4
• Host Species: Mouse
• Isotype: IgG2b
• Quantity: 100 μg
• Storage Requirements: -20° C, Avoid Freeze/Thaw Cycles
• Primary or Secondary: Primary
• Gene ID (Entrez): 55294