Fcμ Receptor Mouse anti-Mouse, PE, Clone: MM3, BD
Mouse Monoclonal Antibody
Manufacturer: BD Biosciences 566030
The MM3 monoclonal antibody specifically binds to the Fc receptor for IgM (Fcμ Receptor, FcμR), which is also known as Fas apoptosis inhibitory molecule 3 (Faim3) or Toso. The Fcμ Receptor is a transmembrane sialoglycoprotein that is encoded by Fcmr (Fc fragment of IgM receptor). This receptor contains an extracellular Ig-like domain that is homologous to two other IgM-binding receptors, the Fc receptor for IgM and polymeric IgA (Fc /μR) and the polymeric Ig receptor (pIgR). Unlike these receptors, the Fcμ Receptor exhibits exclusive binding specificity for the Fc region of IgM. Fcμ Receptor expression is restricted to B lymphocytes. Although expressed by all mature B cell subsets, Fcμ Receptor levels are transiently downregulated by germinal center B cells. This receptor is not expressed by T cells, NK cells, dendritic cells, or myeloid cells.R-phycoerythrin (PE) is an accessory photosynthetic pigment found in red algae. It exists in vitro as a 240-kDa protein with 23 phycoerythrobilin chromophores per molecule. This makes PE one of the brightest fluorochromes for flow cytometry applications, but its photobleaching properties make it unsuitable for fluorescence microscopy.
|Aqueous buffered solution containing ≤0.09% sodium azide.|
|Fcmr, FcmuR, Fcμ Receptor, FcμR, Faim3, Toso|
|Mouse FcμR Transfected Cell Line|
|The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography. The antibody was conjugated with R-PE under optimum conditions, and unconjugated antibody and free PE were removed.|
|Mouse IgG1, κ|
|Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.|
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