FEN1 Mouse anti-Human, Clone: 4E7, Abnova™
Mouse monoclonal antibody raised against full length recombinant human FEN1.
Manufacturer: Abnova Corporation MAB12919
The protein encoded by this gene removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate, thus passing the substrate from one enzyme to another. The protein is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication. DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5' end of the flap that is necessary for both binding and cleavage by the protein encoded by this gene. Therefore, secondary structure can deter the protective function of this protein, leading to site-specific trinucleotide expansions. [provided by RefSeq]
|Mouse monoclonal antibody raised against full length recombinant human FEN1.|
|Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
|Immunohistochemistry (PFA fixed), Western Blot|
|Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (5 ug/mL) Western Blot The optimal working dilution should be determined by the end user.|
|Recombinant protein corresponding to full length human FEN1.|
|Protein G purification|
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