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FEN1 Mouse anti-Human, Clone: 4E7, Abnova™

Mouse monoclonal antibody raised against full length recombinant human FEN1.

Manufacturer:  Abnova Corporation MAB12919

Catalog No. 89-934-134


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Description

Description

The protein encoded by this gene removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate, thus passing the substrate from one enzyme to another. The protein is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication. DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5' end of the flap that is necessary for both binding and cleavage by the protein encoded by this gene. Therefore, secondary structure can deter the protective function of this protein, leading to site-specific trinucleotide expansions. [provided by RefSeq]

Specifications

Specifications

FEN1
4E7
Mouse monoclonal antibody raised against full length recombinant human FEN1.
In PBS.
FEN-1/MF1/RAD2
Mouse
IgG1
50 uL
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
Monoclonal
Human
Immunohistochemistry (PFA fixed), Western Blot
Unconjugated
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (5 ug/mL) Western Blot The optimal working dilution should be determined by the end user.
Liquid
FEN1
Recombinant protein corresponding to full length human FEN1.
Protein G purification
RUO
Primary
2237
SDS
Documents
Product Certifications
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