FEN1 Mouse anti-Human, Clone: OTI1F3, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA526550
DescriptionThe protein encoded by this gene removes 5 ft. overhanging flaps in DNA repair and processes the 5 ft. ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate, thus passing the substrate from one enzyme to another. The protein is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication. DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5 ft. end of the flap that is necessary for both binding and cleavage by the protein encoded by this gene. Therefore, secondary structure can deter the protective function of this protein, leading to site-specific trinucleotide expansions.
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3|
|FEN-1, MF1, RAD2, DNase IV, flap endonuclease 1, hFEN-1, maturation factor 1, maturation factor-1|
|-20° C, Avoid Freeze/Thaw Cycles|
|Immunohistochemistry (Paraffin), Western Blot|
|Human recombit protein fragment corresponding to amino acids 117-380 of FEN1 produced in E.coli|
We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.
Your feedback has been submitted. Fisher Scientific is always working to improve our content for you. We appreciate your feedback.Ok