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FEN1 Mouse anti-Human, Clone: OTI1F3, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA526550

Catalog No. PIMA526550


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Description

Description

The protein encoded by this gene removes 5 ft. overhanging flaps in DNA repair and processes the 5 ft. ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate, thus passing the substrate from one enzyme to another. The protein is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication. DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5 ft. end of the flap that is necessary for both binding and cleavage by the protein encoded by this gene. Therefore, secondary structure can deter the protective function of this protein, leading to site-specific trinucleotide expansions.
Specifications

Specifications

FEN1
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
P39748
FEN-1, MF1, RAD2, DNase IV, flap endonuclease 1, hFEN-1, maturation factor 1, maturation factor-1
Mouse
IgG1
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
2237
Immunohistochemistry (Paraffin), Western Blot
OTI1F3
Unconjugated
FEN1
Liquid
FEN1
Human recombit protein fragment corresponding to amino acids 117-380 of FEN1 produced in E.coli
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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