FERMT3 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Manufacturer: Proteintech Group Inc 181311AP
This antibody works well in WB, IHC and IF applications.The three KINDLINs are a novel family of focal adhesion proteins, localizing to integrin adhesion sites. The KINDLIN proteins are composed of a centrally located FERM domain interrupted by a pleckstrin homology (PH) domain. KINDLIN1 and KINDLIN2 have been shown to play an essential role in integrin-mediated adhesion and spreading. In contrast to the widely expressed KINDLIN1 and KINDLIN2, KINDLIN3 is restricted to hematopoietic cells and is particularly abundant in megakaryocytes and platelets. Several reports describe a transcriptional misregulation of KINDLINs in various types of cancer. A recent study demonstrates that KINDLIN3 is essential for platelet integrin activation and subsequent integrin outside-in signaling, suggesting it may serve as a potential target for the design of therapeutics aimed at specifically disrupting integrin activation in platelets and leukocytes.
|PBS with 50% glycerol and 0.02% sodium azide; pH 7.3|
|Fermitin family homolog 3, FERMT3, KIND3, Kindlin 3, MIG 2, MIG2 like protein, MIG2B, Unc 112 related protein 2, UNC112C, URP2, URP2SF|
|108101, 309186, 83706|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot|
|FERMT3 Fusion Protein Ag12713|
|Antigen Affinity Chromatography|
|Human, Mouse, Rat|
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