FGD1 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA585408

Catalog No. PIPA585408

Description

Keep as concentrated solution. Positive Control: Target recombit protein, U87-MG, SK-N-SH, IMR32, SK-N-AS. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.

FGD1 contains Dbl (DH) and pleckstrin (PH) homology domains. It can bind specifically to the Rho family GTPase Cdc42Hs and stimulate the GDP-GTP exchange of the isoprenylated form of Cdc42Hs. It also stimulates the mitogen activated protein kinase cascade leading to c-Jun kinase SAPK/JNK1 activation. FGD1 has an essential role in embryonic development, and FGD1 gene mutations result in the human developmental disorder, Aarskog-Scott syndrome.

Specifications

• Antigen: FGD1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: FGD1
• Gene Alias: AAS antibody; FGDY antibody; MRXS16 antibody; ZFYVE3 antibody; FGD1 antibody; zinc finger FYVE domain-containing protein 3 antibody; rho/Rac GEF antibody; FYVE; RhoGEF and PH domain-containing protein 1 antibody; rho/Rac guanine nucleotide exchange factor FGD1 antibody; faciogenital dysplasia 1 protein antibody; FYVE; RhoGEF and PH domain containing 1 antibody
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 2245
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.85 mg/mL
• Formulation: 0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: P98174
• Gene Symbols: FGD1
• Immunogen: Recombit protein encompassing a sequence within the C-terminus region of human FGD1.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG