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FGFR3 Mouse anti-Human, Clone: OTI1B10, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA526493

Catalog No. PIMA526493


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Description

Description

This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintece. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia. Three alternatively spliced transcript variants that encode different protein isoforms have been described.
Specifications

Specifications

FGFR3
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
P22607
Fibroblast Growth Factor Receptor 3, ACH, CEK2, HSFGFR3EX, JTK4, FGFR-3, fibroblast growth factor receptor 3 variant 4, hydroxyaryl-protein kinase, tyrosine kinase JTK4, FGF Receptor 3
Mouse
IgG1
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
2261
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
OTI1B10
Unconjugated
FGFR3
Liquid
FGFR3
Human recombit protein fragment corresponding to amino acids 23-375 of FGFR3 produced in SF9 cell
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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