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Fibulin 3 Mouse anti-Human, Clone: OTI1D9, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA525740

Catalog No. PIMA525740


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Description

Description

Fibulin 3, also known as epidermal growth factor (EGF)-containing fibulin-like extracellular matrix protein 1 (EFEMP1), is a member of the fibulin family of extracellular glycoproteins, a group of proteins that are widely distributed and frequently associated with vascular and elastic tissues. The fibulin proteins typically contain a tandem array of EGF-like repeats and a fibulin-type COOH-terminal module. Aberrant accumulation of Fibulin 3 in the endoplasmic reticulum of retinal pigment epithelial cells has been shown to be associated with inherited forms of macular degeneration, but the loss of Fibulin 3 expression does not lead to macular degeneration but rather the appearance of hernias due to a reduction of elastic fibers of fascial connective tissue. Recent experiments have shown that expression of Fibulin 3 promotes tumor growth and may thus be a therapeutic target. At least three isoforms of Fibulin 3 are known to exist. This antibody is predicted to not cross-react with other Fibulin proteins.
Specifications

Specifications

Fibulin 3
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Q12805
DHRD, DRAD, FBLN3, FBNL, MLVT, MTLV, S1-5; EGF-containing fibulin-like extracellular matrix protein 1; FIBL-3; extracellular protein S1-5; fibulin-3
Mouse
IgG2a
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
2202
Flow Cytometry, Western Blot
OTI1D9
Unconjugated
EFEMP1
Liquid
EFEMP1
Full length human recombit protein of EFEMP1 produced in HEK293T cell
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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