Fibulin 3 Mouse anti-Human, Clone: OTI1D9, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA525740
DescriptionFibulin 3, also known as epidermal growth factor (EGF)-containing fibulin-like extracellular matrix protein 1 (EFEMP1), is a member of the fibulin family of extracellular glycoproteins, a group of proteins that are widely distributed and frequently associated with vascular and elastic tissues. The fibulin proteins typically contain a tandem array of EGF-like repeats and a fibulin-type COOH-terminal module. Aberrant accumulation of Fibulin 3 in the endoplasmic reticulum of retinal pigment epithelial cells has been shown to be associated with inherited forms of macular degeneration, but the loss of Fibulin 3 expression does not lead to macular degeneration but rather the appearance of hernias due to a reduction of elastic fibers of fascial connective tissue. Recent experiments have shown that expression of Fibulin 3 promotes tumor growth and may thus be a therapeutic target. At least three isoforms of Fibulin 3 are known to exist. This antibody is predicted to not cross-react with other Fibulin proteins.
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3|
|DHRD, DRAD, FBLN3, FBNL, MLVT, MTLV, S1-5; EGF-containing fibulin-like extracellular matrix protein 1; FIBL-3; extracellular protein S1-5; fibulin-3|
|-20° C, Avoid Freeze/Thaw Cycles|
|Flow Cytometry, Western Blot|
|Full length human recombit protein of EFEMP1 produced in HEK293T cell|
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