Filaggrin, Mouse anti-Human, Alexa Fluor 700, Clone: FLG/1563, Novus Biologicals™

Mouse Monoclonal Antibody

Manufacturer:  Novus Biologicals NBP275774AF700

Catalog No. NB009100

Description

Filaggrin Monoclonal antibody specifically detects Filaggrin in Human samples. It is validated for Immunohistochemistry, Immunohistochemistry (Paraffin).

Specifications

• Antigen: Filaggrin
• Clone: FLG/1563
• Dilution: Immunohistochemistry, Immunohistochemistry-Paraffin
• Formulation: 50mM Sodium Borate with 0.05% Sodium Azide
• Gene Symbols: FLG
• Immunogen: Recombinant human Filaggrin protein fragment (around aa 998-1104) (exact sequence is proprietary)
• Monoclonal or Polyclonal: Monoclonal
• Purification Method: Protein A or G purified
• Regulatory Status: RUO
• Storage Requirements: Store at 4°C in the dark.
• Test Specificity: Filaggrin is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules. Active filaggrin is present at a level of the epidermis where keratinocytes are in transition between the live nucleated granular layer and the anucleate cornified layer, suggesting that filaggrin aids in the terminal differentiation process by facilitating apoptotic machinery.

• Applications: Immunohistochemistry,Immunohistochemistry (Paraffin)
• Conjugate: Alexa Fluor 700
• Format: Purified,Conjugated
• Gene Alias: ATOD2, epidermal filaggrin, filaggrin, Profilaggrin
• Host Species: Mouse
• Isotype: IgG2b Kappa
• Primary or Secondary: Primary
• Quantity: 0.1 mL
• Research Discipline: Cell Biology, Cellular Markers
• Target Species: Human