Filaggrin Antibody (SPM181) - Azide and BSA Free, Novus Biologicals™

Mouse Monoclonal Antibody

Supplier:  Novus Biologicals NBP254365200UG

Catalog No. NB254365200

Description

Filaggrin Monoclonal antibody specifically detects Filaggrin in Human samples. It is validated for Flow Cytometry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin, CyTOF-ready.

Specifications

• Antigen: Filaggrin
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Dilution: Flow Cytometry 0.5 - 1 ug/million cells, Immunocytochemistry/Immunofluorescence 1 - 2 ug/ml, Immunohistochemistry-Paraffin 0.5 - 1.0 ug/ml, CyTOF-ready
• Gene Alias: ATOD2, epidermal filaggrin, filaggrin, Profilaggrin
• Host Species: Mouse
• Purification Method: Protein A or G purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Test Specificity: Filaggrin is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules. Active filaggrin is present at a level of the epidermis where keratinocytes are in transition between the live nucleated granular layer and the anucleate cornified layer, suggesting that filaggrin aids in the terminal differentiation process by facilitating apoptotic machinery.
• Content And Storage: Store at -20 to -80C. Avoid freeze-thaw cycles.
• Isotype: IgG1 κ

• Applications: Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), CyTOF
• Clone: SPM181
• Conjugate: Unconjugated
• Formulation: PBS with No Preservative
• Gene Symbols: FLG
• Immunogen: Recombinant human Filaggrin protein
• Quantity: 200 μg
• Research Discipline: Cytoskeleton Markers
• Gene ID (Entrez): 2312
• Target Species: Human
• Form: Purified

For Research Use Only