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FIS1 Mouse anti-Human, Clone: GT4211, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA527835

Catalog No. PIMA527835


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Description

Description

Positive Control: 293T, A431, HeLa, HepG2 Predicted Reactivity: Mouse (96%), Rat (87%), Rhesus Monkey (100%), Bovine (97%) Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.

Fis1, a 17KDa integral membrane protein, is a novel member of mitochondrial fission machinery. It consists of a central leucine-zipper domain, a coiled-coil region, a tetratricopeptide repeat domain and a C-terminal transmembrane domain. It is a human orthologue of Fis1p (S.cerevisiae) and is localized in the outer mitochondrial membrane. Fis1 acts as a pro-apoptotic factor and plays a vital role in the regulation of mitochondrial fission. It interacts with DLP1 and Mdv1p and facilitates Dnm1p recruitment to the functional fission complex, thereby inducing apoptosis. Role of Fis1 has also been implicated in growth and division of peroxisomes. Loss of Fis1 inhibits apoptosis and results in elongation of mammalian mitochondria.
Specifications

Specifications

FIS1
Monoclonal
2.95 mg/ml
PBS with no preservative
Q9Y3D6
CGI-135, fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae), TTC11
Mouse
IgG2b
100 μl
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
51024
Immunocytochemistry, Immunofluorescence, Western Blot
GT4211
Unconjugated
FIS1
Liquid
FIS1
Full length human FIS1 Recombit protein.
Protein A
RUO
Antibody
Monoclonal
Human
Documents
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