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FLIP Mouse anti-Human, Clone: OTI2H8, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA526676

Catalog No. PIMA526676


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Description

Description

FLIP (CFLAR) is an apoptosis regulator protein which functions as a crucial link between cell survival and cell death pathways in mammalian cells. It acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity.
Specifications

Specifications

FLIP
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
O15519
CASH, CASP8AP1, CLARP, Casper, FLAME, FLAME-1, FLAME1, FLIP, I-FLICE, MRIT, c-FLIP, c-FLIPL, c-FLIPR, c-FLIPS; FADD-like anti-apoptotic molecule; FADD-like antiapoptotic molecule 1; MACH-related inducer of toxicity; caspase homolog; caspase-eight-related protein; caspase-like apoptosis regulatory protein; caspase-related inducer of apoptosis; cellular FLICE-like inhibitory protein; inhibitor of FLICE; usurpin beta
Mouse
IgG1
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
8837
Immunohistochemistry (Paraffin), Western Blot
OTI2H8
Unconjugated
CFLAR
Liquid
CFLAR
Human recombit protein fragment corresponding to amino acids 1-272 of CFLAR produced in E.coli
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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