FLT3 Mouse anti-Human, Clone: BV10A4H2, Abnova™
Mouse monoclonal antibody raised against human FLT3.
Manufacturer: Abnova Corporation MAB12617
This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. The receptor consists of an extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, and a cytoplasmic kinase domain split into two parts by a kinase-insert domain. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. [provided by RefSeq]
|Mouse monoclonal antibody raised against human FLT3.|
|In PBS, 150mM NaCl, pH 7.2 (0.09% sodium azide).|
|Store at 4°C.
Aliquot to avoid repeated freezing and thawing.
|Flow Cytometry, Immunohistochemistry (PFA fixed)|
|Flow Cytometry Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (20 ug/mL) The optimal working dilution should be determined by the end user.|
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